Pharmacology - Immune, endocrine, age

2010/1: What is passive immunisation? What is passive immunisation useful for? What passive immunisation might we consider in the ED?

2009/2: Outline the groups of drugs that are used to treat hyperglycaemia in diabetes mellitus. Contrast the mechanism of action of sulfonylureas and biguanides.

2009/1: In the elderly, what factors change with age and alter pharmacokinetics? Give some examples of drugs commonly used in the emergency department that must have their prescribing altered in the elderly.

2009/1: List the factors affecting placental drug transfer. What is meant by foetal therapeutics? Give examples of drugs administered for this purpose.

2009/1: In children, what factors change with age and alter pharmacokinetics?

2008/2: What are the mechanisms of action of the sulfonynureas? Describe another mechanism. What are the adverse effects of sulfonylurea therapy?

2008/2: How does carbimazole act in thyroid disease? What are the major side effects of carbimazole? How does carbimazole differ from propothiouracil

2006/2: What factors affect drug distribution in the elderly? Give examples of drugs where hepatic clearance does not change with age.

2004/2: Describe the actions of insulin on the liver. What are the complications of insulin therapy?

2004/2: Outline the changes in pharmacokinetics that occur in the elderly. How does the pharmacokinetics of gentamicin change in the elderly?

2003/2: Regarding sulphonylureas and biguanides, compare their mechanisms of action. How do the major side effects of the two groups of drugs differ?

2003/1: What are the different types of oral antidiabetic agents? What is the mechanism of action of the sulfonylureas? How do the biguanides differ from the sulfonylureas in their action? What are the clinical advantages of the different oral antidiabetic agents?