Guidelines, DKA and Cerebral Oedema

Click here for a dive into the DKA cerebral oedema literature and why delayed insulin therapy has been included in guidelines.  And what is the good of guidelines anyway?

Here is a link to the full text relevant article by Edge et al.

A couple of other links to articles below.

  1. Edge JA, Jakes RW, Roy Y, et al. The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children. Diabetologia. 2006;49:2002-2009.
  2. Hom J, Sinert R. Is fluid therapy associated with cerebral edema in children with diabetic ketoacidosis? Annals of Emergency Medicine 2008 52:1 69-75.
  3. Lawrence SE, Cummings EA, Gaboury I, et al. Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis. J Pediatr. 2005;146:688-692.
  4. Glaser N, Barnett P, McClaslin I, et al. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med. 2001;344:264-269.
  5. Duck SC, Wyatt DT. Factors associated with brain herniation in the treatment of diabetic ketoacidosis. J Pediatr 1988;113:10-4.
  6. Rosenbloom A. Intracerebral crises during treatment of diabetic ketoacidosis. Diabetes Care 1990;13:22-33.
  7. White PC, Dickson BA. Low morbidity and mortality in children with diabetic ketoacidosis treated with isotonic fluids. J Paediatrics 2013 163(3): 761-6